IV Ketamine Infusions vs. Intramuscular (IM) Ketamine Injections: What’s The Right Choice For You

Ketamine therapy is changing lives, offering fast relief for depression, PTSD, chronic pain, and anxiety. Two popular ways to receive treatment are intravenous (IV) infusions and intramuscular (IM) injections. Both are effective, but let’s explore what might be the best route for you.

Ketamine IV Infusions

IV infusions are often considered a traditional route in ketamine therapy and hospital use. Here’s why:

• Precise and Adjustable: The dose can be fine-tuned during the session, allowing for real-time adjustments based on how you feel.
• Smooth Delivery: Administered over 40-60 minutes, the effects come on gently.

That said, IV infusions have their challenges:

• Needle in Place: The needle stays in for the entire session, which can feel restrictive or uncomfortable.
• Limited Movement: Being hooked up to an IV means you’re tethered and can’t move freely.
• Abrupt Comedown: When the infusion ends, the rapid drop-off can feel disorienting, cutting your experience short and leaving some people feeling confused.
• Higher Cost: IV infusions often come with a higher price tag due to the equipment and time involved.

Intramuscular (IM) Ketamine Injections

IM injections offer a simpler, more user-friendly experience without sacrificing effectiveness. Here’s why we use IM:

• Quick and Convenient: IM injections take just 5-10 minutes to administer, getting you into your journey faster.
• Freedom to Move: No IV lines mean you’re not tied down, allowing you to find a comfortable position or stretch if needed.
• Smooth Landing: The effects taper off more gradually, creating a more natural and grounded comedown.
• Proven Results: Klarisana published research of 40 patients showing significant symptom reductions:
  • 55% less depression (PHQ-9 scores)
  • 51% less PTSD (PCL-5 scores)
  • 51% less anxiety (GAD-7 scores)
• Cost-Effective: With fewer resources required, IM injections are often more affordable.

While IM injections have a faster onset, which some might find intense, many patients appreciate how quickly they can experience relief.

Comparing the Two Methods

It’s important to note that both IV infusions and IM injections are highly effective at inducing dissociation, a key part of ketamine therapy. Both methods offer comparable results for depression, PTSD, and anxiety, though they may differ slightly in focus. IV infusions, with their adjustable dosing, can sometimes be preferred for managing chronic pain. On the other hand, IM injections often shine for treating anxiety, depression, and PTSD due to their efficiency and smoother recovery.

Route	IM Injections	IV Infusions
Administration Time	5-10 minutes	40-60 minutes
Onset of Effects	Rapid	Gradual
Precision	Pre-measured for consistency	Adjustable during session
Equipment Needed	Simple needle poke (like a flu shot)	IV setup
Cost	More affordable	Higher Priced
Mobility	Full mobility	Limited
Comedown	Gradual and smoother (bell curve)	Abrupt, potentially disorienting

Why Klarisana Prefers IM Injections

At Klarisana, we prioritize a treatment approach that’s not only effective but also accessible and comfortable. IM injections deliver outstanding results without the need for IV equipment, offering a more relaxed and cost-efficient experience for our patients. With their quick administration and smoother comedown, IM injections are a great option for those looking to get the most out of their ketamine therapy.

Ready to Start Your Journey?

Your mental health journey is unique, and we’re here to guide you every step of the way. Reach out to us at Klarisana to learn more about how intramuscular ketamine therapy can help you find relief and rediscover joy.